Accurate proteome-wide missense variant effect ... - Google …
Sep 19, 2023 · The vast majority of missense variants observed in the human genome are of unknown clinical significance. We present AlphaMissense, an adaptation of AlphaFold fine-tuned on human and primate variant population frequency databases to …
A catalogue of genetic mutations to help pinpoint the ... - Google …
Sep 19, 2023 · AlphaMissense is an AI model that classifies the effects of 71 million missense variants, which can affect human protein function. It is based on AlphaFold, a breakthrough model that predicts protein structures, and is available through Ensembl Variant Effect Predictor.
AlphaFold - Google DeepMind
AlphaFold is a deep learning system that can predict protein structures in minutes, with high accuracy. It also provides AlphaFold Server, a tool to explore how proteins interact with biomolecules, and the AlphaFold Protein Structure Database, a free resource for researchers.
GitHub - google-deepmind/alphamissense
AlphaMissense is a model that predicts the pathogenicity of human missense variants using deep learning. This GitHub repository provides the model implementation, data pipeline, and pre-computed predictions for reference.
AlphaMissense
AlphaMissense is a method to predict the pathogenicity of missense variants in proteins based on their structural and evolutionary features. This web resource provides access to AlphaMissense data, hotspot tables, and PyMOL plugin for visualization and download.
DeepMind is using AI to pinpoint the causes of genetic disease
Sep 19, 2023 · DeepMind's AlphaMissense is an AI model that can predict which DNA variations in human genomes are likely to cause disease. The model is based on AlphaFold, a previous AI model for protein...
AlphaFold, meet AlphaMissense: Google DeepMind's AI …
Sep 19, 2023 · Google DeepMind has developed an AI system that predicts the chances that tens of millions of genetic variants will cause disease. Called AlphaMissense, the technolo ...
DeepMind’s New AI Can Predict Genetic Diseases | WIRED
Sep 19, 2023 · AlphaMissense is a machine learning model that can analyze missense variants and predict the likelihood of them causing a disease with 90 percent accuracy—better than existing tools.
Predicting variant pathogenicity with AlphaMissense - Nature
Oct 11, 2023 · A team of researchers from Google DeepMind report in Science the development of AlphaMissense, an artificial intelligence-based approach to predict the pathogenicity of missense variants adapted...
Evaluating DeepMind’s AlphaMissense Classifier - The Golden …
Oct 20, 2023 · Last month, the researchers at Google DeepMind announced the release of AlphaMissense, a new missense prediction algorithm that leverages the protein structure prediction model AlphaFold to distinguish between benign and pathogenic missense variants (Cheng et al., 2023).
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