Four pillars of heart failure: contemporary ... - Open Heart
Mar 2, 2021 · The past two decades have heralded dramatic improvements in outcomes for people living with heart failure with reduced ejection fraction (HFrEF). 1 The more widespread implementation of disease modifying pharmacological therapies,2 supported by landmark trials of renin-angiotensin system inhibitors3 and beta-blockers4 have improved longevity despite a background of an ageing and increasingly ...
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Open Heart is dedicated to publishing high quality, peer reviewed medical research in all disciplines and therapeutic areas of cardiovascular medicine. Research is published across all study phases and designs, from protocols to phase I trials to meta-analyses, including small or specialist studies. Opinionated discussions on controversial ...
Myo-inositol for insulin resistance, metabolic syndrome, polycystic ...
Mar 2, 2022 · Myo-inositol, also known as inositol (cyclohexanehexol), is a cyclic carbohydrate with six hydroxyl groups.1 For a long time, it was considered a B vitamin (vitamin B8). However, it is not considered an essential nutrient because it is formed from glucose. Each kidney makes around 2 g of myo-inositol per day, and the average dietary intake is 0.5–1.0 g/day.2 3 The liver and brain also ...
Vitamin K2—a neglected player in cardiovascular health: a …
Vitamin K2 serves an important role in cardiovascular health through regulation of calcium homeostasis. Its effects on the cardiovascular system are mediated through activation of the anti-calcific protein known as matrix Gla protein. In its inactive form, this protein is associated with various markers of cardiovascular disease including …
Echocardiographic diagnosis of right-to-left shunt using ...
Aug 6, 2020 · Introduction. Patent foramen ovale (PFO) is a common finding with a prevalence of about 25% in the general population.1 A strong association between PFO and ischaemic stroke has been reported.2 Pulmonary arteriovenous malformation (PAVM) is a rare disease in the general population and causes a permanent right-to-left shunt (RLS).3 The association of pulmonary RLS grade on contrast ...
Magnesium for the prevention and treatment of cardiovascular …
Jul 1, 2018 · Magnesium is an essential mineral found in the body. It is naturally present in many foods and is also available as a dietary supplement. 1 It serves as a cofactor in more than 300 enzymatic reactions, such as those responsible for regulating blood pressure, glycaemic control and lipid peroxidation. It is therefore also critical to the …
Harnessing the power of clinical decision support systems: …
Nov 28, 2023 · Clinical decision support systems (CDSSs) are increasingly integrated into healthcare settings to improve patient outcomes, reduce medical errors and enhance clinical efficiency by providing clinicians with evidence-based recommendations at the point of care. However, the adoption and optimisation of these systems remain a challenge. This review aims to provide an overview of the current state ...
Ivermectin may be a clinically useful anti-inflammatory agent for …
Sep 6, 2020 · Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely used in veterinary practice. Anecdotally, the use of the standard clinical dose of ...
Differences of cardiovascular risk assessment in clinical practice ...
Objective Cardiovascular risk estimation is an essential step to reduce the onset of adverse cardiovascular events. For this purpose, the Systematic Coronary Risk Evaluation (SCORE) risk chart method was used in Europe. In 2021, the SCORE2 algorithm was released, bringing changes in the calculation methodology. This study assessed and compared the level of cardiovascular risk in a population ...
Transcatheter mitral valve repair: an overview of current and future ...
Apr 28, 2021 · The field of transcatheter mitral valve repair (TMVr) for mitral regurgitation (MR) is rapidly evolving. Besides the well-established transcatheter mitral edge-to-edge repair approach, there is also growing evidence for therapeutic strategies targeting the mitral annulus and mitral valve chordae. A patient-tailored approach, careful patient selection and an experienced interventional team is ...