15 Department of Radiology. Leiden University Medical Centre, Leiden, The Netherlands 16 Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands ...
Background: Autoantibodies that produce the homogenous pattern on anti-nuclear antibody-indirect immunofluorescence (ANA-IIF) assay using human epithelial cell (HEp-2) substrate are histones, dsDNA ...
A clinical guideline is a document with the aim of guiding decisions based on evidence regarding diagnosis, management and treatment in specific areas of healthcare. Specific to rheumatic and ...
OBJECTIVES To determine whether continued methotrexate treatment increases the risk of postoperative infections or of surgical complications in patients with rheumatoid arthritis (RA) within one year ...
Background: Early therapeutic interventions in inflammatory rheumatic diseases have proven successful in inducing drug-free remission. However, such studies are difficult to conduct in axial ...
Nuclear factor (NF)-κB is a ubiquitous and essential transcription factor whose dysregulation has been linked to numerous diseases including arthritis and cancer. It is therefore not surprising that ...
3 The First Affiliated Hospital of Guangxi Medical University, NanNing, China 4 The Second Affiliated Hospital of Guangxi Medical University, NanNing, China 5 The First Affiliated Hospital of ...
1 Wonkwang University Medical School, Internal Medicine, Iksan, Korea, Rep. of (South Korea) 2 Jeonbuk National University Medical School, Internal Medicine, Jeonju, Korea, Rep. of (South Korea) ...
Background B cells play a pivotal role in autoimmune diseases. In SLE, IFN signature is displayed and aberrant function of Toll-like receptors (TLR) for recognizing nucleic acids contributes to its ...
Modern technological innovations have advanced our understanding of the genetic basis of spondyloarthritis. In ankylosing spondylitis (AS), where the major histocompatibility complex (MHC) accounts ...
Background: Rheumatoid arthritis (RA) is a complex inflammatory disease that modifies body composition. Using the dual-energy x-ray absorptiometry (DXA) in RA patients could be a method for body ...
Background: Imbalance between pro and anti-inflammatory cytokines is an important feature in the pathogenesis of juvenile systemic lupus erythematosus (JSLE). Janus kinases (JAKs) play an important ...