Mike Florio and Devin McCourty react to the latest news out of San Francisco, discussing Brandon Aiyuk’s season-ending injury ...

On Monday, San Francisco 49ers wide receiver Deebo Samuel expressed his support for his injured teammate, Brandon Aiyuk. Head ...

Injuries always have a significant effect on the NFL season, but some teams are bearing the brunt of absences more than others. The San Francisco 49ers are in the midst of what could be classed as an ...

Wide receiver Deebo Samuel played just four snaps in the San Francisco 49ers’ loss to the Kansas City Chiefs on Sunday due to ...

A string of injuries has changed that equation and left the 49ers with few proven options for Brock Purdy to throw the ball ...

Ahead of a visit from the Cowboys, 49ers head coach Kyle Shanahan is revealing the unfortunate news that Deebo Samuel is now ...

Brandon Aiyuk sidelined with knee problem, Deebo Samuel battles pneumonia, and more players remain out of the lineup.

This week’s 49ers mailbag is stocked with questions (and answers) regarding their offensive shortcomings, fourth-quarter ...

The San Francisco 49ers are facing a crisis with Brandon Aiyuk out for the year. Could they trade for Saints WR Chris Olave ...

At linebacker, Dee Winters had his best game of the season while Kyle Shanahan provided a rough timeline for Dre Greenlaw's ...

Even with those ailments of the team’s top three offensive players, the Niners are sizable favorites over the Dallas Cowboys ...