The modulation of neuronal glutamate receptors by phosphorylation is considered to be critical for synaptic plasticity. In particular, altering NMDA–type glutamate receptor properties by ...

As information zings from cell to cell inside the brain, bursts of electricity spur its transmission. At Cold Spring Harbor Laboratory (CSHL), scientists have turned their attention to the tiny pores ...

One of the earliest signs of amyloid-β (Aβ) toxicity is synaptic loss, and recent work from a number of labs has shown that Aβ causes depressed synaptic transmission due to removal of cell surface ...

When it comes to brain proteins, small changes can make a dramatic difference. Researchers studying NMDA (N-methyl-D-aspartate) receptors, which are essential for learning, memory and moment-by-moment ...

A new study suggests a potential molecular strategy for treating fragile X syndrome, an inherited neurodevelopmental disorder that causes autism spectrum disorder and intellectual disability. This ...

An earlier study showed that ketamine, used experimentally, kicked depression in hours instead of weeks. This study showed that a boost in the AMPA receptor is a necessary ingredient. The glutamate ...

D epression can be challenging to treat. Typical antidepressants, which affect levels of chemicals in the brain involved in mood regulation, have been evolving for decades. But recent findings ...

NMDA (short for N-methyl-D-aspartate) receptor antagonists are a class of drugs that may help treat Alzheimer's disease, which causes memory loss, brain damage, and, eventually, death. There's no cure ...

Please provide your email address to receive an email when new articles are posted on . Cognitive recovery was greatest within the first 6 months of diagnosis, persisting up to 36 months. After the 36 ...

Scientists have discovered millions of so-called silent synapses in the adult brain, immature links between neurons that are dormant until they are needed for the formation of new memories. It had ...