The easiest way to track down "when" in a chronic disorder like AD is with the causal quartet, those carrying disease-causing mutations in APP, PSEN1, PSEN2 and SORL1, and, as you expand, including ...

Dennis J. Selkoe, M.D. The Vincent and Stella Coates Professor of Neurologic Diseases, Harvard Medical School. Co-Director, Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s ...

While all three genotypes of mice performed similarly to wild-type animals on multiple behavioral and spatial memory tests, they faltered in tests of working memory. APP-KI had a subtle deficit, which ...

Poor physical health, difficulty with daily routines, and low scores on tests of thinking, memory, and information processing most strongly predict dementia later in life, according to a new report by ...

Erik Johnson at Emory University, Atlanta, agreed MR-SPI is an advance. “The authors’ algorithm addresses a number of challenges with Mendelian randomization using proteomics data. An advantage of ...

Why is age the strongest risk factor for Alzheimer’s disease? In the December 10 Science Signaling, scientists led by Ning Bai, Difei Wang, Yu Di, and Liu Cao at China Medical University in Shenyang, ...

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