BMJ16h
Use of cell permeable NBD peptides for suppression of inflammation
Nuclear factor (NF)-κB is a ubiquitous and essential transcription factor whose dysregulation has been linked to numerous diseases including arthritis and cancer. It is therefore not surprising that ...
BMJ3d
Implementation of recommendations in rheumatic and musculoskeletal diseases: considerations for development and uptake
A clinical guideline is a document with the aim of guiding decisions based on evidence regarding diagnosis, management and treatment in specific areas of healthcare. Specific to rheumatic and ...
BMJ11d
Immune response profiling of patients with spondyloarthritis reveals signalling networks mediating TNF-blocker function in vivo
Objectives Antitumour necrosis factor (TNF) therapy has revolutionised treatment of several chronic inflammatory diseases, including spondyloarthritis (SpA). However, TNF inhibitors (TNFi) are not ...
BMJ4d
Methotrexate and early postoperative complications in patients with rheumatoid arthritis undergoing elective orthopaedic surgery
OBJECTIVES To determine whether continued methotrexate treatment increases the risk of postoperative infections or of surgical complications in patients with rheumatoid arthritis (RA) within one year ...
BMJ11d
Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population
11 WPI Immunology Frontier Research Center, Osaka University, Suita, Japan Objective The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including ...
BMJ6d
Non-invasive imaging in the diagnosis and management of Takayasu’s arteritis
1 Rheumatology Section, The Eric Bywaters Centre, Imperial College London, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK 2 Department of Nuclear Medicine, Faculty of Medicine, Imperial ...
BMJ13d
Clonal haematopoiesis across the age spectrum of vasculitis patients with Takayasu’s arteritis, ANCA-associated vasculitis and giant cell arteritis
Objectives Ageing and inflammation are associated with clonal haematopoiesis (CH), the emergence of somatic mutations in haematopoietic cells. This study details CH in patients with systemic ...
BMJ9d
2016 American College of Rheumatology/European League Against Rheumatism classification criteria for primary Sjögren's syndrome
Objectives To develop and validate an international set of classification criteria for primary Sjögren's syndrome (SS) using guidelines from the American College of Rheumatology (ACR) and the European ...
BMJ9d
EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI): development of a consensus patient index for primary Sjögren's syndrome
Objectives To develop a score for assessment of patients' symptoms in primary Sjögren's syndrome (SS): the EULAR SS Patient Reported Index (ESSPRI). Methods Dryness, pain, somatic and mental fatigue ...
BMJ4d
OP0132 TREAT-TO-TARGET APPROACH ALLOWS TO INDUCE SUSTAINED CLINICAL REMISSION IN OVER 60% OF PATIENTS WITH EARLY AXIAL SPONDYLOARTHRITIS
Background: Early therapeutic interventions in inflammatory rheumatic diseases have proven successful in inducing drug-free remission. However, such studies are difficult to conduct in axial ...
BMJ10d
The novel cytokine interleukin-36α is expressed in psoriatic and rheumatoid arthritis synovium
1 Department of Internal Medicine 3 and Institute for Clinical Immunology, University Hospital of Erlangen-Nuremberg, Erlangen, Germany 2 Department of Clinical Immunology and Rheumatology, Academic ...
BMJ9d
Psoriatic arthritis: epidemiology, clinical features, course, and outcome
1 University of Toronto, Toronto Western Research Institute, Psoriatic Arthritis Program, University Health Network, Centre for Prognosis Studies in the Rheumatic Diseases, Toronto Western Hospital, ...