One of the most surprising results of Week 2 saw the Minnesota Vikings upset the San Francisco 49ers. Sam Darnold and the Vikings offense did their part: Darnold went 17 of 26 for 268 yards, two touchdowns and an interception;

Vikings defensive coordinator Brian Flores told his defense to "do what we've been doing and a little bit more" as Minnesota seeks a 3-0 start to the regular season for

San Francisco hits the road for the first time on a short week. Here is our 49ers vs. Vikings prediction and best bet for NFL Week 2.

The San Francisco 49ers are looking to end a nearly 32-year drought with a road victory Sunday against the Minnesota Vikings.

The San Francisco 49ers (1-0) and the Minnesota Vikings (1-0) square off at U.S. Bank Stadium on Sunday, September 15, 2024. The 49ers and the Vikings play at 1 p.m. ET. NFL STATS CENTRAL: The latest NFL scores, schedules, odds, stats and more.

Minnesota has been a house of horrors for the San Francisco 49ers for decades. The Niners' eighth straight loss in the Twin Cities looked an awful out like the one a year ago. The Vikings flummoxed Brock Purdy with their pressure packages and burned the San Francisco defense with a big passing play.

The Minnesota Vikings pulled off an upset over the San Francisco 49ers in Week 2, 23-17. However, perhaps the biggest storyline after the game was the injury to Vikings superstar wide receiver Justin Jefferson.

The Minnesota Vikings are now 2-0, but they’ve lost Justin Jefferson and Dallas Turner to injuries. How long will they be sidelined?