Week 6 has plenty of intriguing matchups on deck, and already is off the heels of the New York Giants upsetting the Philadelphia Eagles on Thursday night. That just goes to show you that anything can unfold after kickoff,

The 49ers (4-1) travel across the country to face the Bucs (4-1), and both teams are coming off entertaining 3-point wins on the road. The 49ers — despite being riddled with injuries on offense — won Thursday night over the Rams as huge underdogs. Mac Jones filled in again for quarterback Brock Purdy and the 49ers offense looked good.

The Buffalo Bills take on the Atlanta Falcons in the first of two Monday Night Football games to close out Week 6 of the NFL season.

DFS millionaire Mike McClure has also locked in his top picks for the Week 6 NFL DFS main slate, and he's building around Rico Dowdle and Puka Nacua. Get his picks right here.

The Jets offense was a disaster in a 13-11 loss to the Broncos in London. Will it change versus the Panthers? Here are our predictions for Week 7.

The Chicago Bears and the Washington Commanders face off on Monday Night Football to close out Week 6 of the NFL season.

SportsLine expert PropBetGuy, who is on a 32-20 run on his last 52 NFL player props, has revealed his top prop picks for Week 6