"The capsaicin or piperine (from the chili or black pepper) activates pain receptors (TRPV1) that create the burning ...

Touch a hot plate and your hand flies back. While the response is almost instant, researchers are still working to better understand the molecular mechanisms behind these sensations of heat and pain.

The endocannabinoid system is one of the most diffuse neurotransmitter systems in the body and the brain. Understanding its ...

The endocannabinoid system is the body’s system that regulates an array of other systems in the body. It works to maintain homeostasis by the use of receptors, cannabinoids, and metabolic pathways ...

Before being discontinued, the P2X7 receptor blocker had cleared a master protocol study in chronic pain, though Eli Lilly ...

Sometimes pain is a necessary warning signal; for example, if we touch something very hot and it burns, we know to move our hand away. But chronic pain can destroy a person's quality of life, and it ...

Treating mice with a molecule that rescued autophagy and balanced neuronal excitability reduced pain behaviors, offering a ...

A new opioid-free pain medication was approved by the U.S. Food and Drug Administration (FDA) on Thursday, marking a non-addictive alternative for patients. Journavx (suzetrigine), made by Vertex, is ...

COLUMBUS, Ohio – Hotter temperatures may render natural insect repellents less effective against mosquitoes, according to a new study. Researchers found that a pain receptor called TRPA1 becomes less ...

Removing human pain receptors could end chronic suffering but might reduce life expectancy, as pain serves as a vital signal ...