"It is fascinating that these tight junction proteins behave in a very similar way to water. Putting together our ...

A team led by Prof. Wang Chao and Prof. Huang Chengdong from the University of Science and Technology of China (USTC) of the ...

AK132 is a bispecific antibody developed by Akeso, targeting the recombinant humanized Claudin18.2 (CLDN18.2) splice variant 2 and CD47 for the treatment of various cancers, including gastric, ...

The stress of heat and oxidative damage during exercise causes disruption to intestinal epithelial cell tight junction proteins resulting in increased permeability to luminal endotoxins. The endotoxin ...

Claudin-6 (CLDN6) is a tight junction protein that has been found to be up-regulated in around 20 different types of cancer, among them ovarian, endometrial and germ cell tumors. Conventional T-cell ...

The FDA has approved a new drug called zolbetuximab designed to attack a novel target that’s in a type of stomach cancer.

It is a four-pass transmembrane protein that has been expressed at the epithelial-endothelial tight junction and is a component of tight junction strands, which are important for signal ...

Takahashi's team has previously discovered a new protein complex within the synaptic junction, called TrkC-PTPσ, which is ...