Preclinical data demonstrate enhanced efficacy of PLT012 in pMMR colorectal cancer models - Findings position CD36 as a promising metabolic checkpoint target in an underserved patient population DOVER ...

Immune system activation and activity is regulated through stimulatory or inhibitory ligand-receptor interactions collectively termed immune checkpoints. 1 Stimulatory interactions give the immune ...

A proprietary monoclonal antibody targeting an inhibitory immune checkpoint pathway had favorable safety and tolerability in ...

Narcolepsy is a rare disorder of central hypersomnolence which is often under-recognised owing to a variable clinical phenotype. Narcolepsy type 1 (NT1) is caused by loss of hypothalamic hypocretin ...

TAE Life Sciences (TLS), a leader in Boron Neutron Capture Therapy (BNCT), today announced the publication of new research in ACS Pharmacology & Translational Science (an ACS journal), demonstrating ...

Patients with advanced HER2-negative gastric cancer respond differently to immunotherapy based on whether they are Asian or ...

New research has uncovered immune changes in cancer patients that could help identify which patients are most at risk of dangerous heart complications from cancer drugs, known as immune checkpoint ...

A new metabolic mechanism describes how tumors disable “gatekeeper” cells to prevent immune response to cancer.

St. Jude Children's Research Hospital scientists have discovered how tumors disable immune "gatekeeper" cells that alert the ...