A patent ductus arteriosus is due in large part to increased sensitivity of the premature ductus to PGE2. After PGE2 stimulation, cAMP concentrations are higher in the immature than in the mature ...

Infants with symptomatic PDA who failed or could not get ibuprofen treatment, and who were candidates for surgical ligation, were administered oral paracetamol 15 mgkg –1 every 6h, for up to 7 days ...

Patent ductus arteriosus (PDA), one of the more common cardiac defects present at birth, is the persistence of an opening between the pulmonary artery and aorta. This opening is as a result of failure ...

SHOULD closure of a patent ductus arteriosus with reversal of flow be attempted? If so, how can the high surgical mortality hitherto reported 1–3 be reduced? An attempt is made to answer these ...