San Lorenzo is a city, with a population of 35,560, and a municipality in the Honduran department of Valle. The city was established by Spaniard…San Lorenzo is a city, with a population of 35,560, and a municipality in the Honduran department of Valle. The city was established by Spaniards as a village in 1522 but not granted city status until 1909. It is the primary Honduran port on the Pacific coast and lies on the Pan American Highway.