La Prairie is a city in Itasca County, Minnesota, United States. The population was 653 at the 2020 census. U.S. Highways 2 and 169 ar…La Prairie is a city in Itasca County, Minnesota, United States. The population was 653 at the 2020 census. U.S. Highways 2 and 169 are two of the main routes in La Prairie. A post office was in operation at La Prairie from 1890 until 1917. The community was named after the nearby Prairie River.