The Río Plátano Biosphere Reserve is a protected area in the La Mosquitia region on the Caribbean coast of Honduras. With a total area of 5,250 square kilometers, most of the reserve runs along the Río Plátano. The reserve has a number of endangered species and some of the largest remnants of tropical forest in Central America. It has been a World H…The Río Plátano Biosphere Reserve is a protected area in the La Mosquitia region on the Caribbean coast of Honduras. With a total area of 5,250 square kilometers, most of the reserve runs along the Río Plátano. The reserve has a number of endangered species and some of the largest remnants of tropical forest in Central America. It has been a World Heritage Site and biosphere reserve since 1982. In 2011, UNESCO placed the reserve on the List of World Heritage in Danger.