Animal models of heart failure with preserved ejection fraction (HFpEF …
WEBAug 29, 2023 · A novel HFpEF animal model that combined aging, obesity (HFD feeding) and hypertension (DOCP, 75 mg/kg) in C57BL/6 J mouse has been reported.
Common Heart Failure With Preserved Ejection Fraction Animal Models ...
WEBJan 9, 2024 · HFpEF animal models historically emphasized hypertension and ventricular hypertrophy to achieve diastolic dysfunction, and recently have incorporated obesity and diabetes as they are increasingly prevalent.
Animal models of heart failure with preserved ejection fraction (HFpEF …
WEBThis review provides an updated overview of the currently available animal models of HFpEF and discusses their characteristics from the perspective of energy metabolism. Interventional strategies for efficiently utilizing energy substrates in preclinical HFpEF models are also discussed.
Heart Failure With Preserved Ejection Fraction: Heterogeneous …
WEBJun 10, 2022 · Instead of expecting a single animal model to reproduce all aspects of the diverse clinical manifestations of the HFpEF syndrome, we propose that model development should be multifold and focus on capturing the hallmark features of specific phenogroups in clinical HFpEF.
Murine Models of Heart Failure With Preserved Ejection Fraction
WEBDec 25, 2017 · An “ideal” animal model should meet various requirements to mimic human disease, including cardiac, hemodynamic, neurohormonal, and peripheral aberrations commonly seen in HFpEF patients . However, similar to humans, a “one-size-fits-all” strategy is unlikely to work in animal models.
Animal models of heart failure with preserved ejection fraction
WEBMar 2, 2016 · In this review, we present an overview of the currently available animal models that are employed in the study of HFpEF, including rodent and large animal models, and discuss the strengths and weaknesses of these models.
Animal models of heart failure with preserved ejection fraction
WEBIn this review we will provide an overview of the currently available models to study HFpEF from rodents to large animals as well as present advantages and disadvantages of these models. Keywords: Animal models, Rodents; Diastolic dysfunction; Heart failure with preserved ejection fraction.
Large animal models of heart failure with preserved ejection fraction
WEBNov 9, 2021 · In this review, we highlight currently available methodologies in producing large animal HFpEF models, focusing on surgical technique, and we evaluate their advantages and disadvantages as a preclinical step for the future development of HFpEF therapies in humans.
Heart failure with preserved ejection fraction: present status …
WEBDec 19, 2019 · Researchers have examined molecular events in the development of HFpEF using small and middle-sized animal models. This review discusses HFpEF with regard to etiology and clinical features and...
Mouse Model of Heart Failure With Preserved Ejection Fraction …
WEBSep 3, 2022 · We present a novel murine model wherein diastolic dysfunction and classic symptoms of HFpEF are induced by pharmacological inhibition of combined with cardiac‐specific overexpression of LDLR.
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